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目的探讨血清超敏C-反应蛋白(hs-CRP)、肌钙蛋白Ⅰ(cTnⅠ)及肌酸激酶同工酶(CK-MB)联合检测在急性心肌梗死(AMI)诊断中的临床价值。方法对38例心肌梗死胸骨后疼痛发作2～6h的患者及48例心肌梗死胸骨后疼痛发作12～24h的患者采用免疫散射比浊定量法检测其血清CPR,采用免疫抑制法检测CK-MB,采用免疫荧光法检测其血清cTnⅠ,并与39例正常对照组进行比较。结果两AMI组患者的CRP、cTnⅠ及CK-MB浓度较正常对照组高;联合检测CRP+CK-MB、CRP+cTnⅠ+CK-MB、cTnⅠ+CRP阳性检出率均为100.0%。结论联合检测hs-CRP、cTnⅠ在AMI早期诊断中有很高的特异性及灵敏度,可作为AMI的预后监测及疗效观察的指标。
Objective To investigate the clinical value of combined detection of serum hs-CRP, cTnI and CK-MB in the diagnosis of acute myocardial infarction (AMI). Methods Serum CPR was measured by immunostaining turbidimetry in 38 patients with post-sternal pain episode of 2 ~ 6h after myocardial infarction and 48 patients with post-sternal pain recurrence of 12 ~ 24h after myocardial infarction. The levels of CK-MB, Serum cTnI was detected by immunofluorescence and compared with 39 normal controls. Results The concentrations of CRP, cTnI and CK-MB in two AMI groups were higher than those in normal control group. The positive rates of CRP + CK-MB, CRP + cTnⅠ + CK-MB and cTnⅠ + CRP were both 100.0%. Conclusions The combined detection of hs-CRP and cTnI has high specificity and sensitivity in the early diagnosis of AMI, and can be used as an indicator of prognosis monitoring and curative effect of AMI.