目的探讨结肠黑变病的相关致病因素。方法对经结肠镜检出的44例结肠黑变病的临床资料、镜下表现及病理进行回顾性分析。结果44例中28例便秘,26例有服用泻药史,病变累及全结肠者40例,并发结直肠息肉10例,溃疡性结肠炎1例。结论结肠黑变病主要与便秘、滥用泻药外,可能与结肠息肉,溃疡性结肠炎也有关。 Objective To investigate the related pathogenic factors of colonic melanosis. Methods The clinical data, microscopic findings and pathology of 44 cases of colonic melasma detected by colonoscopy were retrospectively analyzed. Results Of the 44 cases, 28 cases had constipation, 26 cases had history of laxatives, 40 cases had lesions involving the whole colon, 10 cases had colorectal polyps, and 1 case had ulcerative colitis. Conclusion Colitis mellitus is mainly associated with constipation and abuse of laxatives, which may be related to colonic polyps and ulcerative colitis.