在与临床的密切接触中,发现有的制剂疗效不够理想,但又没有合适的替代药;在制剂配制中,发现有的工艺技术不够完善。我们利用现有条件,进行了一些改进,取得了成效。 水杨酸软膏 水杨酸是治疗浅部真菌感染的常用药物。其软膏剂一直采用传统处方以凡士林为基质配制,临床疗效不够满意。凡士林属油脂性基质,释放药物的性能较差,适用于皮肤表层治疗药物的基质。皮肤真菌感染多在角质层内,药物需从基质中释放出来扩散到皮肤上,再穿透入角质层内,并在角质层内达到一定浓度,才能有效发挥抗菌作用,取得疗效。为此,我们改用了释放药物性能较好的乳剂基质,并将水杨酸以少量二甲基亚砜溶 In close contact with the clinic, some agents were found to be less effective than the others, but there was no suitable alternative medicine. Some of the techniques found in the formulation were not perfect. We use the existing conditions, made some improvements, and achieved results. Salicylic acid ointment Salicylic acid is a commonly used drug for the treatment of superficial fungal infections. Its ointment has been using traditional prescription with Vaseline as matrix, the clinical effect is not satisfactory. Vaseline is an oily matrix that delivers poorer drug delivery properties and is suitable for use as a matrix for skin surface treatments. Skin fungal infections are mostly in the stratum corneum, the drug needs to be released from the matrix spread to the skin, and then penetrate into the stratum corneum, and reach a certain concentration within the stratum corneum in order to effectively play an antimicrobial effect and achieve efficacy. To this end, we switched to the release of better drug emulsion matrix, and salicylic acid in a small amount of dimethyl sulfoxide