喉癌(laryngeal carcinoma)是一种常见的上呼吸道恶性肿瘤。据JEMAL等报道,每4例头颈部肿瘤患者中就有1例是喉癌[1]。肿瘤的发生是一个多因素参与的复杂过程。目前已知,在喉癌的发生演进过程中,除致癌环境这一外源性因素外,原癌基因的扩增、抑癌基因的失活或突变、错配修复基因 Laryngeal carcinoma is a common upper respiratory tract malignancy. According to JEMAL et al., 1 out of 4 patients with head and neck cancer is laryngeal cancer [1]. Tumor occurrence is a complex process involving multiple factors. It is known that in the process of evolution of laryngeal carcinoma, in addition to the exogenous factors of carcinogenic environment, proto-oncogene amplification, inactivation or mutation of tumor suppressor gene, mismatch repair gene