【摘 要】
：
Objective: This study aimed to explore safflower injection (SI) for constituents with activity against ischemic stroke using a combination of chemical analysis
【机 构】
：
State Key Laboratory of Natural Medicines,School of Traditional Chinese Pharmacy,China Pharmaceutica
论文部分内容阅读
Objective: This study aimed to explore safflower injection (SI) for constituents with activity against ischemic stroke using a combination of chemical analysis and a network pharmacology strategy. Materials and Methods: The main ingredients of SI were comprehensively identified using ultra?high?performance liquid chromatography coupled with quadrupole time?of?flight tandem mass spectrometry, and the core targets and pathways associated with stroke were predicted using PharmMapper and Kyoto Encyclopedia of Genes and Genomes analysis. Cytoscape software was used to visualize and analyze the active compound?target?pathway network of SI regulating ischemic stroke. Results: A total of 76 chemical compounds were identified from the SI sample, including 63, which regulated 88 targets that were ultimately enriched in 12 key ischemia stroke?related signaling pathways. Kaempferol?3?O?sophoroside, kaempferol?3?O?rutinoside, carthamoside B6, neoeriocitrin, and 6?hydroxykaempferol?3?O?rutinoside?6?O?glucoside were determined to be important for stroke treatment because they had a higher degree value in the network than other constituents did. Moreover, the characteristic components isolated from SI showed protective effect mainly by acting on multiple targets including AKT1, epidermal growth factor receptor, transforming growth factor?beta receptor (TGFBR), Ras homolog, mTORC1 binding, caspase 3, and glycogen synthase kinase 3 beta, which were involved in different signaling pathways including phosphoinositide 3?kinase?Akt, mitogen?activated protein kinase, neurotrophin, ErbB, mechanistic target of rapamycin, and tumor necrosis factor. Conclusions: This study proposed a network pharmacology and chemical component profiling strategy for the systematic understanding of the therapeutic material basis of using SI against ischemic stroke.
其他文献
目的:探讨循证干预在新生儿重症监护室(NICU)危重患儿有创动脉血压监测中的应用效果及其对患儿QOL评分的影响。方法:选取2017年6月~2019年6月某院NICU收治的危重患儿82例,所有患儿均给予有创动脉血压监测,按照随机数字表法将入组患儿分为对照组和研究组各41例,对照组给予常规护理,研究组给予循证干预,比较两组患儿QOL评分。结果:研究组QOL评分高于对照组(P<0.05)。结论:在NICU危重患儿有创动脉血压监测中应用循证干预,能够提高患儿QOL评分,具有较高的应用价值。
本文通过比较添加不同浓度外源硒下香菇不同菌种的生长情况,确定了添加外源硒的种类和适宜浓度,筛选出适宜宁夏地区栽培的富硒香菇菌种;同时,总结了富硒香菇原种及栽培种制作技术,旨在为富硒香菇生产提供技术支撑,从而促进宁夏食用菌产业可持续发展。
Objective: To explore the mechanism underlying the effect of Panax notoginseng saponins (PNS) on the pharmacokinetics of nifedipine (NF) in rats. Materials and
目的:分析老年心力衰竭患者采用超声检查评价其左心形态、功能。方法:选取2017年12月~2018年12月期间某院收治的老年心力衰竭患者80例,左心室收缩性、舒张性心衰者分别作为收缩组和舒张组各40例,再选同期体检的健康者40例为对照组,均行心脏彩超检查,比较检查结果。结果:LAD、LVD、IVST、PWT、APFV、IRT等各项指标水平方面,收缩组、舒张组均明显高于对照组;而EPFV、LVEF、E/A、CI、DC水平方面,收缩组、舒张组均低于对照组,差异均有统计学意义(P<0.05)。结论:老年心力
目的:探讨手部运动在经桡动脉冠脉介入患者术后康复护理中的应用效果。方法:选择某院从2020年1月~11月收治的107例经桡动脉行冠脉介入手术患者,按照随机数字表法将其分为研究组54例和对照组53例,对照组给予常规护理,研究组在进行常规护理基础上接受手部运动康复训练,比较两组患者术后4h、8h、12hVAS评分、肿胀评分以及术后24h出血率。结果:研究组术后4h、8h、12hVAS评分、肿胀评分均低于对照组(P<0.05);研究组术后24h内出血率为12.96%、对照组为22.64%(P>0.0
为降低生产成本、减轻土壤污染、增加农民收入,开展了玉米生产中化肥减量、增施有机肥的效益研究。结果表明:化肥减量15%、配施有机肥1800 kg/hm2玉米产量最高,为12713.8 kg/hm2,较常规施肥增产1.4%,净收益增加558.37元/hm2。减施化肥、合理增施有机肥可以提高玉米产量、增加收益。
金太阳杏是早熟甜杏新品种,在高台县干旱荒漠地区引种,其适应性好,其经济效益高。文章对高台县干旱荒漠区金太阳杏栽培技术进行了概括总结,以期对西北地区同类地貌绿化和杏树栽培起到参考作用。
分别以河沙、蛭石、蛭石+珍珠岩(9∶1)为基质,进行不同基质对欧李嫩枝扦插育苗生根的影响试验,结果表明:成活苗木中,蛭石+珍珠岩基质欧李生根效果最好,生根率为86.67%;河沙基质欧李新枝最长、最粗,分别为18.63 cm、1.81 mm;蛭石+珍珠岩基质苗木根最粗,为3.10 mm;河沙基质苗木生根数量最多、根长最长,为9.22条和25.40 cm。以生根率为主要指标,蛭石+珍珠岩为欧李嫩枝扦插最佳基质。考虑成苗后生长指标及成本因素,也可选用河沙作为欧李嫩枝扦插基质,河沙作基质时,在炼苗期管理中注意补充
针对宁夏引黄灌区的气候特点,结合金叶榆树冠丰满、颜色艳丽及高度抗寒冷、抗干旱、耐碱性的特性,从苗圃地规划与选择、砧木选材与定植、嫁接及田间管理、病虫害防治等方面介绍了宁夏引黄灌区金叶榆嫁接培育技术。
铁是植物生长所必需的微量元素之一,由于土壤的理化性质以及铁元素含量的差异,导致植物对铁的吸收效率较低,而在一些铁污染的土壤中,铁却对植物产生严重的毒害作用。本文通过对植物吸收转运铁的分子机制及其相关基因的功能进行综述,以期在植物缺铁胁迫和铁毒害的基因调控转录机制方面提供一定的理论依据,对后期培育耐受缺铁胁迫或铁毒害的植物有一定的参考意义。