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丁香园报道,二甲双胍治疗可改善糖尿病患者心肌梗死后的结局,而且,在动物实验研究中,二甲双胍可保护左心室功能。然而,二甲双胍对非糖尿病患者心功能的影响尚不清楚。为此,来自荷兰格罗宁根大学医学中心的van der Horst教授及其团队进行了一项研究,探讨二甲双胍治疗对无糖尿病的ST段抬高型心肌梗死(STEMI)患者左心室功能的影响。研究结果在线发表在2014年03月3 1日的the Journal of the American Medical Association杂志上。该研究是2011年01月01日至2013年05月26日期间在荷兰格罗宁根大学医学中心进行的一项双盲、安慰剂对照研究,受试者为380例因STEMI接受直接经皮
Clove Park reported that metformin treatment can improve the outcome of diabetic patients after myocardial infarction, and, in animal studies, metformin can protect the left ventricular function. However, the impact of metformin on heart function in nondiabetic patients is not clear. To this end, Professor van der Horst from the University of Groningen Medical Center in the Netherlands and his team conducted a study to investigate the effect of metformin on left ventricular function in patients with STEMI without diabetes. The findings were published online in the Journal of the American Medical Association March 31, 2014. The study was a double-blind, placebo-controlled study at the University of Groningen Medical Center in the Netherlands from January 01, 2011 to May 26, 2013. The study included 380 patients who underwent direct percutaneous