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目的探讨细胞免疫功能的变化与原因不明习惯性流产(unexplained habitual abortion,UHA)的发生及主动免疫治疗机制的关系。方法2002-08-2004-08汕头大学医学院第一附属医院采用流式细胞仪测定并比较112例UHA患者和30例正常已生育妇女及76例经主动免疫治疗后的UHA患者外周血CD3+、CD4+、CD8+、CD16+CD56+细胞亚群比例及CD4+/CD8+的比值;同时比较76例采用主动免疫治疗和36例未采用主动免疫治疗的UHA者再次妊娠成功率。结果UHA患者与正常已生育妇女比较,血中CD3+、CD16+CD56+细胞的百分率及CD4+/CD8+比值增高,差异有显著性意义(P<0·05)。主动免疫后CD3+、CD16+CD56+细胞百分率及CD4+/CD8+比值下降(P<0.05)。经主动免疫治疗的UHA者再次妊娠成功率为88.24%,对照组为31.25%,两组比较差异有非常显著性意义(P<0.01)。结论淋巴细胞亚群比例的改变与UHA的发生有关,主动免疫治疗可调节异常的细胞免疫功能,有利于提高再次妊娠成功率。
Objective To investigate the relationship between the changes of cellular immune function and the occurrence of unexplained habitual abortion (UHA) and the mechanism of active immunotherapy. Methods 2002-08-2008-08 The First Affiliated Hospital of Shantou University Medical College was used to measure and compare the peripheral blood CD3 + in 112 UHA patients, 30 normal pregnant women and 76 UHA patients after active immunotherapy. CD4 +, CD8 +, CD16 + CD56 + cell subsets and CD4 + / CD8 + ratio; 76 cases of active immunization and 36 cases without active immunotherapy UHA active pregnancy rate again. Results The percentage of CD3 +, CD16 + CD56 + cells and the ratio of CD4 + / CD8 + in blood of UHA patients were significantly higher than those of normal pregnant women (P <0.05). After active immunization, the percentage of CD3 +, CD16 + CD56 + cells and the ratio of CD4 + / CD8 + decreased (P <0.05). The successful pregnancy rate of UHA after active immunotherapy was 88.24% and that of control group was 31.25%. There was significant difference between the two groups (P <0.01). Conclusion The change of lymphocyte subsets is related to the occurrence of UHA. Active immunotherapy can regulate abnormal cellular immune function and improve the success rate of pregnancy again.