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乙型肝炎病毒侵入人体后,易形成持续性感染,并诱发各种慢性肝脏疾患。这种持续慢性感染状态,是由于被感染者机体免疫系统对乙型肝炎病毒的特异性耐受所造成。主要是由于两个方面因素:一是机体免疫系统对乙型肝炎病毒识别、加工和递呈环节存在障碍;二是病毒感染使宿主细胞免疫信息传递以及病毒变异使得免疫攻击效应减弱或丧失。
Hepatitis B virus invades the human body, easy to form a persistent infection, and induce a variety of chronic liver disease. This persistent state of chronic infection is due to the specific tolerance of the host’s immune system to the hepatitis B virus. Mainly due to two factors: First, the immune system of the host of hepatitis B virus identification, processing and presenting obstacles; second is the virus infection host cell immune information transmission and virus mutation makes the immune attack effect weakened or lost.