目的分析子痫前期患者血清中内源性硫化氢(hydrogen sulfide,H_2S)的表达水平。方法选取在潍坊市妇幼保健住院分娩的115例孕妇为研究对象。实验组80例(包括轻度子痫前期患者42例,重度子痫前期患者38例),对照组35例为正常妊娠孕妇。比较两组孕妇血清中H_2S的表达水平。结果 1子痫前期患者血清中H_2S浓度明显低于对照组(P<0.05),差异有统计学意义。2重度子痫前期组的变化最明显。3实验组H_2S浓度与疾病严重程度呈明显负相关(P<0.05)。结论子痫前期患者血清H_2S的表达水平下降,其下降水平与病情轻重关系密切,参与妊娠期高血压疾病的发生、发展。 Objective To analyze the expression of endogenous hydrogen sulfide (H2S) in the serum of preeclampsia patients. Methods A total of 115 pregnant women who were hospitalized in Maternal and Child Health Care Hospital of Weifang City were selected as the research object. 80 cases (including 42 cases of mild preeclampsia and 38 cases of severe preeclampsia) in the experimental group and 35 cases of normal pregnant women in the control group. The serum levels of H 2 S in the two groups were compared. Results Serum H 2 S concentration in preeclampsia patients was significantly lower than that in the control group (P <0.05), and the difference was statistically significant. 2 severe preeclampsia group changes the most obvious. The concentration of H 2 S in the experimental group was significantly negatively correlated with the severity of the disease (P <0.05). Conclusions The expression level of serum H 2 S in preeclampsia patients is decreased. The level of H 2 S is closely related to the severity of the disease. It is involved in the occurrence and development of hypertensive disorder complicating pregnancy.