By using coordinate transformation method, this paper obtains an useful equation of designing meta-material cloaks embedded in anisotropic medium. This equation is the generalization of what was introduced early by Pendry et al (2006 Science 312 1780) and can be more widely used. As an example of its applications, this paper deduces the material parameter equation for cylinder cloaks embedded in anisotropic medium, and then offers the numerical simulation. The results show that such a cylinder cloak has perfect cloaking performance and therefore verifies the method proposed in this paper.