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目的:观察参附注射液对NP方案治疗非小细胞肺癌的减毒作用。方法:对42例非小细胞肺癌患者随机分为2组,各21例。观察1组第1周期用参附注射液加NP方案治疗,第2周期单纯用NP方案治疗;观察2组第1周期单纯用NP方案治疗,第2周期用参附注射液加NP方案治疗。主要观察参附注射液对NP方案毒性的影响。结果:参附注射液加NP方案的白细胞、中性粒细胞毒性和恶心呕吐、便秘症状均较NP方案低,差异有显著性或非常显著性意义(P<0．05,P<0．01),其余各项两方案相近(P>0．05)。观察1组参附注射液加NP方案的白细胞、中性粒细胞毒性、恶心呕吐和便秘症状均较单纯用NP方案低,第1周期与第2周期比较,差异有显著性意义(P<0．05)。气虚痰湿型患者中,参附注射液加NP方案的白细胞、中性粒细胞毒性较单纯用NP方案低,差异有显著性意义(P<0．05)。结论:参附注射液能减轻NP方案治疗非小细胞肺癌的血液学和消化道毒性,对气虚痰湿型患者的减毒作用较明显。早期联合应用参附注射液,减毒作用更好。
Objective: To observe the attenuated effect of Shenfu injection on NP regimen in the treatment of non-small cell lung cancer. Methods: Forty-two patients with non-small cell lung cancer were randomly divided into two groups (n = 21 each). The first cycle of group 1 was treated with Shenfu injection plus NP regimen, the second cycle was treated with NP regimen alone. The second cycle was treated with NP regimen alone and the second regimen was treated with Shenfu injection plus NP regimen. The main observation of Shenfu injection NP program toxicity. Results: The symptoms of leukocyte, neutrophil toxicity, nausea and vomiting and constipation of Shenfu injection combined with NP regimen were lower than those of NP regimen, the difference was significant or very significant (P <0.05, P <0.01 ), The rest of the two programs are similar (P> 0.05). Observation group 1 Shenfu injection plus NP regimen leukocyte, neutrophil toxicity, nausea and vomiting and constipation symptoms were lower than the simple NP regimen, the first cycle and the second cycle, the difference was statistically significant (P <0 .05). Qi deficiency phlegm type patients, Shenfu injection plus NP regimen of leukocytes, neutrophil toxicity than simple NP program, the difference was statistically significant (P <0.05). Conclusion: Shenfu injection can reduce the hematologic and gastrointestinal toxicity of NP regimen in the treatment of non-small cell lung cancer, and has an obvious attenuating effect on patients with qi deficiency and phlegm-dampness. Early joint Shenfu injection, attenuated better.