论文部分内容阅读
目的探讨血清C反应蛋白(C-RP)、白细胞介素-18(IL-18)与代谢综合征(MS)的关系。方法通过检测128例MS患者(MS组)和130例非MS患者(CG组)的血清C-RP、IL-18、血脂、体重指数(BMI)、胰岛素抵抗指数等指标,比较两组患者血清C-RP、IL-18的差异。结果 MS组DBP、SBP、WHR、BMI、WC、FPG、Fins、2hPG、TG、HOMA-IR、IL-18、C-RP水平均高于CG组,差异具有统计学意义(P<0.05),MS组HDL-C水平低于CG组,差异具有统计学意义(P<0.05)。回归分析结果示:血清C-RP、IL-18均为MS的独立影响因素。结论 C-RP、IL-18参与的慢性炎症反应可能是MS的病因之一。
Objective To investigate the relationship between serum C-reactive protein (C-RP), interleukin-18 (IL-18) and metabolic syndrome (MS). Methods Serum C-RP, IL-18, serum lipids, body mass index (BMI) and insulin resistance index were measured in 128 MS patients and 130 non-MS patients. C-RP, IL-18 differences. Results The levels of DBP, SBP, WHR, BMI, WC, FPG, Fins, 2hPG, TG, HOMA-IR, IL-18 and C-RP in MS group were significantly higher than those in CG group (P <0.05) The level of HDL-C in MS group was lower than CG group, the difference was statistically significant (P <0.05). Regression analysis showed that: serum C-RP, IL-18 are independent factors of MS. Conclusion The chronic inflammatory reaction involving C-RP and IL-18 may be one of the causes of MS.