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目的 观察恒定均匀磁场对异丙肾上腺素 (ISO)致急性心肌损伤的影响。方法 用注射ISO造成急性心肌损伤的动物模型 ,观察磁场对心肌组织丙二醛 (MDA)及ATP、血红细胞超氧化物歧化酶(SOD)、血肌酸磷酸激酶 (CK)及对心肌组织损伤的影响。结果 磁场组SOD活力及ATP分别为 (60 7.4± 98.6)U/g·HB-1、(4 .2± 0 .7)nmol/mg·ww-1,显著高于ISO组的 (4 4 3 .5± 91 .2 )U/g·HB-1、(3 .1± 0 .6)nmol/mg·ww-1(P <0 .0 1 )。磁场组MDA、CK水平分别为 (61 .3± 7.9)nmol/mg·ww-1、(73 2 .4± 1 89.3 )U/L ,显著低于ISO组的 (98.6± 1 1 .4)nmol/mg·ww-1、(1 3 58.9± 2 3 1 .5)U/L。同时磁场组的组织损伤较轻。结论 恒定均匀磁场能有效地抑制ISO致动物心肌损伤 ,对心肌有一定的保护作用。
Objective To observe the effect of constant magnetic field on acute myocardial injury induced by isoproterenol (ISO). Methods The model of acute myocardial injury caused by injection of ISO was observed. The effect of magnetic field on myocardial malondialdehyde (MDA) and ATP, erythrocyte superoxide dismutase (SOD), serum creatine phosphokinase (CK) Impact. Results The SOD activity and ATP in the magnetic field group were (60 7.4 ± 98.6) U / g · HB-1 and (4.2 ± 0.7) nmol / mg · ww-1, respectively, which were significantly higher than those in the ISO group .5 ± 91 .2) U / g · HB-1, (3 .1 ± 0.6) nmol / mg · ww-1 (P <0.01). The levels of MDA and CK in the magnetic field group were (61.3 ± 7.9) nmol / mg · ww-1 and (73.2 ± 4.489.3) U / L, respectively, which were significantly lower than those in the ISO group (98.6 ± 11.4) nmol / mg · ww-1, (1 3 58.9 ± 2 3 1 .5) U / L. At the same time the magnetic field group of tissue damage less. Conclusion The constant magnetic field can effectively inhibit the myocardial injury induced by ISO and protect the myocardium.