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目的探讨累加角度头高斜位暴露下 ,正常人体血压、心率、脑血流及心率变异性 (HRV)变化特征 ,为建立飞行员晕厥检查的方法学提供生理依据。方法采用自行研制的多功能双向式医用倾斜床 ,结合先进的十二导联同步心电图描记方法和经颅多普勒脑血流成像技术进行累加角度 ( + 4 5°→ 60°→75°)头高斜位 (HUT)暴露下的心率、血压、HRV和脑血流速率的测量与分析。结果 1 )随着倾斜角度加大 ,暴露时程延长 ,HR逐渐增快 ,SBP逐渐下降 ,DBP逐渐升高 ,PP逐渐缩小 ,与暴露前比较 ,HR、PP和DBP相差非常显著 (P <0 .0 5 ) ;脑血流速率 (包括 :Vs、Vm、Vd)逐渐下降 ,无论与暴露前比 ,或倾斜角度之间比 ,差异十分显著 (P <0 .0 1 ) ;mRR和sdRR逐渐减小。 2 )生理指标与技术指标直线相关分析发现 :在 1min时 ,SBP、DBP、MAP、Vd、sdRR与倾斜角度呈明显正相关 (P <0 .0 1 ) ;在 2 0min时 ,HR和sdRR与倾斜角度呈明显正相关 (P <0 .0 1 ) ,与SBP、PP、Vs、mRR明显负相关 (P <0 .0 1 ) ;暴露时程与HR呈明显正相关 (P <0 .0 1 ) ,与SBP、Vm、Vd、mRR呈明显负相关 (P <0 .0 1 )。 3)生理指标间相关分析发现 :HR与SBP、Vs、Vm、Vd 呈明显负相关 (P <0 .0 1 ) ;SBP与Vd 和mRR呈明显正相关 (P <0 .0 1 ) ;Vs、Vm、Vd 与mRR和sdR
Objective To investigate the changes of HRV in normal human subjects exposed to cumulative angle of head-upper oblique exposure, and to provide a theoretical basis for establishing the methodology of pilots syncope examination. Methods The self-developed multi-functional bi-directional medical tilt bed was used to carry out the cumulative angle (+4 5 ° → 60 ° → 75 °) with advanced 12-lead synchronous electrocardiography and transcranial Doppler cerebral blood flow imaging. Measurement and Analysis of Heart Rate, Blood Pressure, HRV and Cerebral Blood Flow Velocity in Hypertensive Hypertension (HUT) Exposure. Results 1) As the tilt angle increased, the duration of exposure prolonged, HR gradually increased, SBP decreased gradually, DBP increased gradually, PP gradually decreased. Compared with before exposure, the difference of HR, PP and DBP was significant (P <0 (P <0.01). The ratio of cerebral blood flow (including Vs, Vm and Vd) decreased gradually, no matter with pre-exposure ratio or inclination angle (P <0.01); mRR and sdRR gradually decreased Decrease 2) The linear correlation analysis of physiological indexes and technical indicators showed that the SBP, DBP, MAP, Vd and sdRR were positively correlated with the tilt angle at 1 min (P <0.01); at 20 min, HR and sdRR were (P <0.01), but negatively correlated with SBP, PP, Vs and mRR (P <0.01). There was a significant positive correlation between exposure duration and HR (P <0. 0) 1), but negatively correlated with SBP, Vm, Vd and mRR (P <0.01). 3) Correlation analysis showed that there was a significant negative correlation between HR and SBP, Vs, Vm, Vd (P <0.01); SBP was positively correlated with Vd and mRR (P <0.01); Vs , Vm, Vd and mRR and sdR