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目的探讨阿司匹林肠溶片联合双嘧达莫对脑血栓患者神经功能恢复及血液流变学的影响。方法抽取2013年12月~2016年10月北京市仁和医院198例脑血栓患者,根据治疗方案分为观察组和对照组,每组99例。对照组在常规治疗基础上给予阿司匹林肠溶片治疗,观察组在对照组基础上联合双嘧达莫治疗。对比两组治疗前后神经功能缺损程度(NIHSS)评分、全血黏度(高切、低切)、血小板聚集率、红细胞比容(HCT)水平、生活质量(SF-36)评分,并统计两组治疗期间不良反应发生率。结果观察组治疗总有效率95.96%(95/99)高于对照组87.88%(87/99),差异有统计学意义(P<0.05);两组治疗后评分均有所降低,但观察组低于对照组,差异有统计学意义(P<0.05);治疗后两组全血高切、低切黏度,血小板聚集率,HCT差异有统计学意义(P<0.05);两组恶心/呕吐、上腹部不适、头晕/头痛及皮肤瘙痒发生率差异均无统计学意义(P>0.05);观察组治疗后SF-36生活质量各领域评分均高于对照组,差异有统计学意义(P<0.05)。结论给予脑血栓患者阿司匹林肠溶片联合双嘧达莫治疗,有利于改善血液流变学指标水平、促进神经功能恢复,且安全性高,利于患者生活质量的提高。
Objective To investigate the effects of aspirin enteric-coated tablets combined with dipyridamole on neurological function recovery and hemorheology in patients with cerebral thrombosis. Methods A total of 198 cerebral thrombosis patients from Renhe Hospital of Beijing from December 2013 to October 2016 were divided into observation group and control group according to the treatment plan, with 99 cases in each group. The control group was given aspirin enteric-coated tablets on the basis of routine treatment. The observation group was treated with dipyridamole on the basis of the control group. The NIHSS score, whole blood viscosity (high and low cut), platelet aggregation rate, hematocrit (HCT) level and quality of life (SF-36) score were compared between the two groups before and after treatment. The incidence of adverse reactions during treatment. Results The total effective rate in the observation group was 95.96% (95/99), which was significantly higher than that in the control group (87.88%, 87/99) (P <0.05). The scores of both groups decreased after treatment, but the observation group (P <0.05). After treatment, there were significant differences in high shear rate, low shear viscosity, platelet aggregation rate and HCT between the two groups (P <0.05). The nausea / vomiting (P> 0.05). The scores of SF-36 quality of life in the observation group were higher than those in the control group (P <0.05), and the difference was statistically significant (P> 0.05). There was no significant difference in the incidence of upper abdominal discomfort, dizziness / headache and pruritus <0.05). Conclusions Administration of aspirin enteric-coated tablets combined with dipyridamole in patients with cerebral thrombosis is beneficial to improve the level of hemorheology indexes, promote neurological function recovery, and is safe and conducive to the improvement of patients’ quality of life.