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目的探讨2型糖尿病患者糖化血红蛋白(HbA1c)与尿微量蛋白之间的关系。方法选取2009年6月至2010年5月门诊及住院部收治的2型糖尿病患者80例,按HbA1c水平分为6.5%≤HbA1c≤7.0%组(42例)和HbA1c≥8.0%组(38例),测定HbA1c和空腹血糖、餐后2h血糖及尿微量蛋白水平并进行分析。结果 HbA1c≥8.0%组空腹及餐后2h血糖、尿微量蛋白水平明显高于6.5%≤HbA1c≤7.0%组(P均<0.01)。结论同时测定HbA1c及尿微量蛋白水平对血糖监测和早期肾损伤的诊断和预防有重要临床意义。
Objective To investigate the relationship between glycated hemoglobin (HbA1c) and urinary microalbuminuria in type 2 diabetic patients. Methods Eighty patients with type 2 diabetes treated in outpatient department and inpatient department from June 2009 to May 2010 were divided into 6.5% ≤HbA1c≤7.0% (n = 42) and HbA1c≥8.0% (n = 38) according to the level of HbA1c ), HbA1c and fasting blood glucose, 2h postprandial blood glucose and urine microalbumin levels were determined and analyzed. Results The fasting blood glucose and urine microalbuminuria of HbA1c≥8.0% group were significantly higher than those of 6.5% ≤HbA1c≤7.0% (P <0.01). Conclusions Simultaneous determination of HbA1c and urinary microalbumin levels has important clinical significance for the diagnosis and prevention of blood glucose monitoring and early renal injury.