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应用双抗体夹心法测定113例I～N级脑胶质瘤患者手术前后脑脊液(CSF)可溶性白细胞介素2受体(sIL-2R)水平。结果发现脑胶质瘤患者术前CSF中sIL-2R水平均高于对照组。且升高程度与肿瘤分级有明显关系(P<0.01);术后sIL-2R水平均有不同程度下降,其中I～N级者尤为明显(P<0.01);术后sIL-2R水平再次升高预示肿瘤复发;肿瘤囊液中sIL-2R水平高于CSF中sIL-2R水平,两者呈正相关(均P<0.05)。提示检测CSF中sIL-2R水平,对推测脑胶质瘤的恶性程度及早期发现肿瘤复发有一定意义。
The levels of soluble interleukin 2 receptor (sIL-2R) in cerebrospinal fluid (CSF) of 113 patients with grade Ⅰ ~ N glioma before and after operation were measured by double antibody sandwich method. The results showed that glioma patients with sIL-2R levels were higher than the control group. (P <0.01). The level of sIL-2R decreased after operation, especially in I ~ N level (P <0.01). The level of sIL-2R increased again High predictive tumor recurrence; sIL-2R levels in tumor cystic fluid higher than sIL-2R levels in CSF, both were positively correlated (P <0.05). Prompt detection of CSF sIL-2R levels, speculated that the degree of malignancy of gliomas and early detection of tumor recurrence of some significance.