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建立一种新的胃癌细胞功能分类方法；探索胃癌细胞功能分化特征与其病理生物学行为，特别与局部侵袭和远隔转移的关系。方法：按胃癌细胞的功能分化方向，将361例胃癌分为5种类型。结果：①吸收功能分化型(AFDT):82例，占本组资料的22.7%；此型中中老年男性占92.7%，84.1%为肠型胃癌，46.3%表达CD44v6；属此型的男性中13.6%(9/66)伴肝脏转移；术后5年生存率(58.5%)明显高于除特殊功能分化型(SFDT)胃癌以外的其他型，(P<0.01)。②粘液分泌功能分化型(MSFDT):54例，占全组的15%,以局部垂直向胃壁深层侵袭为主，手术时绝大多数(98.1%，53/54)已侵透浆膜，术后5年生存率为28.6%。③吸收-粘液产生功能双向分化型(AMPFDT):180例，占全组的49.9%，<45岁的青年患者(17.2%)和女性(34.4%)明显多于其他型；雌激素受体表达率(71.7%,129/180)明显高于其他型；女性中19.4%(12/62)伴有卵巢转移，术后5年生存率最低(24.7%)。④特殊功能分化型(SFDT):13例，占全组的3.6%；69.2%(9/13)属APUD来源，30.7%(4/13)为不同形态学分化的胃癌；术后5年生存率为60%。⑤无功能分化型(NFDT):32例，占全组的8.9%；其中19例(59.4%)伴转移，且均为淋巴结转移，而未见肝或卵巢转移；术后5年生存率为28.1%。结论：利用作者建议的胃癌细胞功
A new functional classification method for gastric cancer cells was established; the functional differentiation characteristics and pathological biological behavior of gastric cancer cells were explored, especially the relationship between local invasion and distant metastasis. Methods: According to the functional differentiation direction of gastric cancer cells, 361 cases of gastric cancer were divided into 5 types. RESULTS: 1 Absorption functional differentiation type (AFDT): 82 cases, accounting for 22.7% of the data in this group; this type of middle-aged and elderly men accounted for 92.7%, 84.1% for intestinal type gastric cancer, 46.3% for CD44v6 expression; in this type of male 13.6% (9/66) had liver metastases; postoperative 5-year survival rate (58.5%) was significantly higher than other types except for special function differentiation type (SFDT) gastric cancer (P<0.01). 2 Mucus secreting function differentiation type (MSFDT): 54 cases, accounting for 15% of the whole group, with local vertical invasion to the deeper stomach wall. The vast majority (98.1%, 53/54) have invaded the serosa during surgery. The 5-year survival rate was 28.6%. 3 Absorption-mucus production function Two-way differentiation type (AMPFDT): 180 cases, accounting for 49.9% of the whole group, <45-year-old young patients (17.2%) and women (34.4%) were significantly more than other types; estrogen receptor expression The rate (71.7%, 129/180) was significantly higher than other types; 19.4% (12/62) of women had ovarian metastasis, and the 5-year survival rate was the lowest (24.7%). 4Special function differentiation type (SFDT): 13 cases, accounting for 3.6% of the whole group; 69.2% (9/13) belonged to the source of APUD, 30.7% (4/13) were gastric cancers with different morphological differentiation; 5-year survival after operation The rate is 60%. 5 No function differentiation type (NFDT): 32 cases, accounting for 8.9% of the whole group; 19 cases (59.4%) with metastasis, and all were lymph node metastasis, but no liver or ovary metastasis; postoperative 5-year survival rate 28.1%. Conclusion: Using the author’s suggestion of gastric cancer cell function