怀孕3个月时使用孕激素是否会增加胎儿畸形的危险性,目前尚有争议。作者收集了382名使用孕激素预防流产的妇女的生育结果。她们均接受过孕酮(P)阴道栓剂或肌肉内注射17羟孕酮(17-OHP),如果临床或实验室检查证明需要增加孕激素用量,则阴道栓剂增加17-OHP使用。有时因为局部有副作用(如瘙痒),只使用17-OHP。在患者血清雌二醇水平达到200pg/ml/每成熟卵泡,和超声证明卵泡直径为18～24mm的3、4天后,开始孕激素治疗。开始时,每人每天的用量最低是50mg,而且,在用P前,一般均经过声谱仪sonographic检查证实有卵释放。在成熟卵泡形成后18天,如果经β-亚单位人绒毛膜促性腺激素证实已经妊娠,孕酮用量将增至100mg/天。17-OHP的用量为500mg/周。根据临 Pregnancy 3 months when using progesterone will increase the risk of fetal malformations, is still controversial. The authors collected fertility results from 382 women using progestin to prevent abortion. They both received pessary (P) vaginal suppository or intramuscular injection of 17-hydroxyprogesterone (17-OHP), and vaginal suppositories increased use of 17-OHP if clinical or laboratory tests demonstrated the need for increased progestin levels. Sometimes with side effects (such as itching), only 17-OHP is used. The progestin therapy begins when the patient serum estradiol levels reach 200 pg / ml per mature follicle, and 3,4 days after sonication of follicular diameter 18-24 mm. Initially, the lowest daily dose per person is 50mg, and, in the use of P, the sonographic examination of sonography have generally been confirmed egg release. On day 18 after the mature follicle is formed, the progesterone dosage will be increased to 100 mg / day if confirmed by β-subunit human chorionic gonadotropin as already pregnant. The amount of 17-OHP was 500 mg / week. According to Pro