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应激性溃疡是创伤或外科手术后患者发病的一个重要原因.虽然绝大多数应激性溃疡看来都由胃粘膜屏障缺陷引起,但发生在颅脑外伤后的病例有一点甚为独特,即伴有高胃酸分泌,其发生机制尚未清楚.作者设计一种模型,对清醒和麻醉后动物造成控制性颅内高压,以研究其对胃酸分泌和胃泌素释放的作用.材料和方法:30只新西兰种兔完成实验,另有15只因各种原因未计入本资料.18只静脉点滴尿烷麻醉(麻醉组).另12只在进行手术操作时给硫苯妥钠静脉麻醉,创口内用0.5%丁哌卡因液浸润.收集胃液前待其恢复知觉,然后在整个实验过程中保持清醒状态(清醒组).
Stress ulcers are an important cause of morbidity in patients after trauma or surgery Although the vast majority of stress ulcers appear to be caused by gastric mucosal barrier defects, the cases that occur after traumatic brain injury are somewhat unique, That is accompanied by high gastric acid secretion, the mechanism is not yet clear. The authors designed a model of awake and anesthetized animals caused by controlled intracranial hypertension to study its role in gastric acid secretion and gastrin release.Materials and Methods: 30 New Zealand breeds of rabbits completed the experiment, and another 15 were not included in this data for various reasons .18 intravenous urethane anesthesia (anesthesia group) .Other 12 during the operation to intravenous thiophenal sodium anesthesia, The wounds were infiltrated with 0.5% bupivacaine solution, and the gastric juice was collected for recovery and then awake (awake group) throughout the experiment.