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目的探讨脑梗死患者颈动脉内膜中层厚度(CIMT)与氧化应激参数及相关危险因素之间的关系。方法采用彩色多普勒超声测量脑梗死100例患者CIMT,根据CIMT值分为CIMT正常组(CIMT<1.0mm)和CIMT增厚组(CIMT≥1.0mm),比较二组患者年龄、血清中丙二醛(MDA)、谷胱甘肽(GSH)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)等指标。结果脑梗死患者中CIMT增厚的患者占62%,CIMT正常的占38%(P<0.005);同时CIMT增厚组患者年龄、TC、LDL、MDA明显高于CIMT正常组(P<0.05);GSH水平明显低于CIMT正常组(P<0.05);而二组TG、HDL水平差异无统计学意义(P>0.05)。结论 CIMT增厚与脑梗死密切相关,脑梗死患者CIMT增厚受多种因素影响,尤其与年龄、TC、LDL水平密切相关,氧化应激损伤可能参与了脑梗死患者动脉粥样硬化的发生发展,是CIMT增厚的重要因素之一。
Objective To investigate the relationship between carotid intima-media thickness (CIMT) and oxidative stress and related risk factors in patients with cerebral infarction. Methods CIMT was measured in 100 patients with cerebral infarction by color Doppler ultrasonography and divided into CIMT normal group (CIMT <1.0mm) and CIMT thickening group (CIMT≥1.0mm) according to CIMT value. The age, MDA, GSH, TC, TG, LDL and HDL were measured. Results Patients with cerebral infarction had 62% of patients with thickened CIMT and 38% of patients with normal CIMT (P <0.005). At the same time, age, TC, LDL and MDA of CIMT patients were significantly higher than those of CIMT patients (P <0.05) ; GSH level was significantly lower than that of normal CIMT group (P <0.05); while TG and HDL levels of the two groups had no significant difference (P> 0.05). Conclusions CIMT thickening is closely related to cerebral infarction. The thickening of CIMT in patients with cerebral infarction is affected by many factors, especially the age, TC and LDL levels. Oxidative stress may be involved in the development of atherosclerosis in patients with cerebral infarction , Is one of the important factors of CIMT thickening.