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关节假体周围感染是关节置换术后灾难性的并发症.目前对于关节假体周围感染尚缺乏一种可靠、迅捷、高准确率的诊断方法.美国骨肌系统感染协会(Musculoskeletal Infection Society,MSIS)制定的关节假体周围感染诊断标准获得国内外学者的普遍认可,但其诊断指标相对复杂不便于临床应用.临床上常用血沉、血清CRP、IL6、降钙素原等实验室指标辅助诊断关节假体周围感染,但这些指标的异常并不完全由关节假体周围感染引起,易受其他炎性因素影响.近年来,滑液生物标志物,尤其是滑液α-防御素对关节假体周围感染的诊断价值逐渐受到重视.本文综合分析目前关于滑液α-防御素的临床研究,就其在关节假体周围感染诊断中的研究现状及临床价值做一综述.“,”Peri-prosthetic infection is a catastrophic complication after joint replacement.We currently lack a reliable,fast,and highly accurate method of diagnosis for peri-prosthetic infection.The diagnostic criteria of peri-prosthetic infection established by American Musculoskeletal Infection Society (MSIS) are well recognized by scholars both domestically and abroad.However,their relatively complex indices make them inconvenient for clinical applications.Laboratory markers such as erythrocyte sedimentation rate,and the serum level of C-reactive protein,interleukin-6,and procalcitonin are usually used to assist with the diagnosis of peri-prosthetic infection.But these markers are not only influenced by the infection,but also affected by other inflammatory factors.In recent years,the value of synovial fluid oα-defensin level in the diagnosis of peri-prosthetic infection has gradually been taken seriously.In this article,we reviewed current clinical studies related to synovial fluid α-defensins,and analyzed the effect and application prospect of α-defensins in the diagnosis of peri-prosthetic infection.