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目的：了解临床上各类型肝病患者血清中肝纤维化的状况。对正常人、急性肝炎、慢性肝炎轻度、慢性肝炎中度、肝硬化、慢性重症型肝炎和原发性肝癌患者各50例进行了血清中透明质酸酶（HA）、人Ⅲ型前胶原（HPCⅢ）和Ⅳ—型胶原（Ⅳ—C）的定量检测。方法；采用放射免疫分析法（RNA），以第二抗体作为分离剂测定血清中纤维化指标的含量。结果：除慢性重症型肝炎患者的HPCⅢ稍为降低外，其余HA、HPCⅢ和Ⅳ—C都随着病程的延长而逐渐升高。结论：结果提示血清中HA、HPCⅢ和Ⅳ—C的含量可能在很大程度上反映出肝纤维化的严重程度，为临床诊断，治疗有关疾病提供依据．
Objective: To understand the status of liver fibrosis in the serum of patients with various types of liver diseases. Serum hyaluronidase (HA) and human type III procollagen were performed on 50 cases of normal persons, acute hepatitis, mild chronic hepatitis, moderate chronic hepatitis, moderate liver cirrhosis, chronic severe hepatitis and primary liver cancer. Quantitative detection of (HPCIII) and type IV collagen (IV-C). Methods: Using radioimmunoassay (RNA), the second antibody was used as a separating agent to determine the content of fibrosis markers in serum. RESULTS: Except for a slight decrease in HPCIII in patients with chronic severe hepatitis, the remaining HA, HPCIII, and IV-C all gradually increased with prolonged course of the disease. Conclusion: The results suggest that the serum levels of HA, HPCIII and IV-C may reflect the severity of hepatic fibrosis to a large extent, providing a basis for clinical diagnosis and treatment of related diseases.