癌易感基因(susceptibilitygenesofcancer)即决定对患癌易感性的基因。迄今已知道有2类癌易感基因。一类为高外显率、高危险度易感基因,也可称为主效基因;另一类为低外显率、低危险度易感基因,也可称为微效基因。一般认为,前者在家族性癌发生中起重要作用,后者则与癌的发生发展 Susceptibility genes (susceptibility genes) that determine the susceptibility to cancer genes. To date, two types of cancer susceptibility genes have been known. One is the high penetrance, high risk susceptibility genes, also known as the main effect gene; the other is low penetrance, low risk susceptibility genes, also known as the micro-gene. It is generally believed that the former plays an important role in the development of familial carcinomas, while the latter is associated with the development of cancer