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目的探讨凝血酶联合奥美拉唑治疗残胃出血的临床疗效。方法选取贵港市第二人民医院2014年6月—2016年5月收治的残胃出血患者72例,按入院顺序将患者分为对照组与观察组,各36例。对照组予以奥美拉唑治疗,观察组患者凝血酶联合奥美拉唑治疗,比较两组患者临床效果、实验室血氧分压(PaO_2)、尿微量清蛋白(U-ALB)、D-二聚体及止血时间,观察不良反应发生情况。结果观察组患者治疗效果高于对照组(P<0.05),观察组患者PaO_2、U-ALB低于对照组,D-二聚体高于对照组,止血时间短于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用凝血酶联合奥美拉唑治疗残胃出血的临床疗效确切,可有效改善患者临床症状,缩短止血时间,安全性高。
Objective To investigate the clinical efficacy of thrombin combined with omeprazole in the treatment of residual gastric hemorrhage. Methods Seventy-two patients with residual gastric hemorrhage who were treated in Guigang Second People’s Hospital from June 2014 to May 2016 were selected and divided into control group and observation group according to admission sequence, with 36 cases in each group. The patients in the control group were treated with omeprazole and the patients in the observation group were treated with thrombin and omeprazole. The clinical effects, PaO_2, U-ALB and D- Dimer and hemostasis time to observe the occurrence of adverse reactions. Results The therapeutic effect of the observation group was higher than that of the control group (P <0.05). PaO2 and U-ALB in the observation group were lower than those in the control group. D-dimer was higher in the observation group than in the control group, and the bleeding time was shorter than that in the control group (P <0.05). The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusions The clinical efficacy of thrombin combined with omeprazole in the treatment of residual gastric hemorrhage is definite, which can effectively improve the clinical symptoms, shorten the time of hemostasis and have high safety.