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沙门菌是一种革兰阴性肠道病原菌,其通过“触发”机制,依赖沙门菌致病岛(Salmonella pathogenicity island,SPI)编码的Ⅲ型分泌系统(typeⅢsecretion system,T3SS)将效应蛋白转运至宿主细胞,调节宿主细胞功能。SopB是SPI-1编码的效应分子之一,其在沙门菌侵袭宿主细胞过程中发挥多重生物学功能,如介导细胞骨架重排,促使Akt发生磷酸化修饰进而抑制细胞凋亡,激活一氧化氮合酶(iNOS),并能诱导沙门菌包含小泡(Salmonella containing vacuole,SCV)的初步形成及成熟,为沙门菌在宿主细胞内的存活及增殖提供了一个微环境。
Salmonella is a Gram-negative enteric pathogen that translocates effector proteins via a type III secretion system (T3SS) encoded by the Salmonella pathogenicity island (SPI) through the “triggering” mechanism To the host cell to regulate host cell function. SopB is one of the effector molecules encoded by SPI-1, which plays multiple biological functions in the process of Salmonella invasion of host cells, such as mediating cytoskeleton rearrangement, promoting phosphorylation of Akt to inhibit apoptosis, activating the oxidation of monoxide (INOS), and can induce the initial formation and maturation of Salmonella containing vacuole (SCV), providing a microenvironment for the survival and proliferation of Salmonella in host cells.