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最近作者报告了一种无需注射器的免疫接种方法——经皮免疫接种 ,即将疫苗抗原涂于完整皮肤上。大多数蛋白质对皮肤是弱免疫原 ,已证实加入粘膜佐剂霍乱毒素 ( CT)能使机体对佐剂和共同接种抗原产生细胞和体液免疫应答。作者以白喉类毒素 ( DT)和破伤风类毒素 ( TT)为模型抗原?
The authors recently reported a syringe-free immunization method - transdermal immunization, which involves applying vaccine antigens to intact skin. Most proteins are weak immunogens on the skin and it has been demonstrated that addition of the mucosal adjuvant cholera toxin (CT) has enabled the body to produce both a cellular and humoral immune response to adjuvants and co-vaccination of antigens. The author of diphtheria toxoid (DT) and tetanus toxoid (TT) as a model antigen?