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血栓素 A_2(TxA_2)有很强的血管收缩、血小板聚集和溶膜作用,其释放可使心肌缺血与损伤范围扩大。近来报告 TxA_2不仅在缺血损伤开始时重要,对再灌注损伤也起重要作用。本文报告 BM13505即4-[2-(4-chlorobenzenesulfonylamino)ethyl]-benzeneacetic acid,一种 TxA_2/内过氧化物受体拮抗剂,防止猫急性心肌缺血与再灌注损伤。
Thromboxane A 2 (TxA 2) has a strong vasoconstriction, platelet aggregation and membrane-dissolving effect, and its release can make myocardial ischemia and injury range expanded. Recent reports that TxA_2 is important not only at the onset of ischemic injury but also on reperfusion injury. This article reports BM13505, a 4- (2- (4-chlorobenzenesulfonylamino) ethyl] -benzeneacetic acid, a TxA 2 / endoperoxide receptor antagonist that protects against acute myocardial ischemia and reperfusion injury in cats.