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对肾综合征出血热沙鼠肾细胞Ⅰ型灭活疫苗,在推广应用时应注意的两个问题进行了观察。第一,对免疫病理发生的危险性通过对接种组发生的病例调查和对两次流行高峰前、后接种人群双份血清检测EHF.VIgG的结果证实再感染的存在,但无ADE发生。第二,在免疫策略方面对疫苗型别的选择与疫苗质量的控制、简化免疫程序、基础免疫与加强注射的时间,接种的对象等提出了建议,供推广应用时参考。
Hemorrhagic fever with renal syndrome type I inactivated gerbil kidney cell vaccine in the promotion of the application of two issues should be noted. First, the risk of immunopathology is measured by a case-by-case study of the vaccinated group and by double sera from two vaccinated populations before and after the two pre-epidemic peak. The results of VIgG confirmed the presence of reinfection, but no ADE occurred. Second, we put forward suggestions on how to choose the type of vaccines, how to control the quality of the vaccine, how to simplify the immunization procedure, how to improve the immunization, how to improve the vaccination, and how to vaccinate.