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目的探讨具不同肝硬化背景的肝癌患者血浆中纤维蛋白原(Fibrinogen,FBG)水平差异及其临床意义。方法采用全自动血凝分析仪检测48例正常人、104例肝硬化患者、243例肝癌合并肝硬化患者、61例肝癌无肝硬化患者的FBG,分析四组间血浆FBG水平的差异;并分析FBG水平与是否合并肝硬化、肝功能分级、原发灶大小、肝内血管癌栓形成情况、肝癌分期间的相关性。结果肝硬化组、正常对照组、肝癌合并肝硬化组、肝癌无肝硬化组的血浆FBG水平依次升高;肝功能分级越差、原发灶越大、肝内血管癌栓越多、肝癌分期越晚的患者血浆FBG水平越高,差异均具有统计学意义(P<0.05)。结论肝癌患者具有高纤维蛋白原血症的特点,肝癌有无肝硬化背景与患者血浆FBG水平相关,血浆FBG水平可能成为肝癌发生发展、浸润转移的预测性指标之一。
Objective To investigate the plasma levels of fibrinogen (Fibrinogen, FBG) in patients with liver cirrhosis and their clinical significance. Methods The automatic blood coagulation analyzer was used to detect the plasma levels of FBG in 48 normal controls, 104 patients with liver cirrhosis, 243 patients with hepatocellular carcinoma and 61 patients with hepatocellular carcinoma without cirrhosis. FBG levels with or without cirrhosis, classification of liver function, size of primary tumor, intrahepatic vascular thrombus formation, and correlation between liver cancer stages. Results The level of plasma FBG in cirrhosis, normal control, hepatocellular carcinoma with cirrhosis, and cirrhosis without liver cirrhosis increased successively. The worse the grade of liver function, the larger the primary tumor, the more intrahepatic vascular embolism, The later the patients with higher plasma FBG levels, the differences were statistically significant (P <0.05). Conclusion The patients with HCC have the characteristics of high fibrinogen, the cirrhosis of liver cancer is related to the level of plasma FBG in patients, and the level of plasma FBG may be one of the predictive indicators for the development, invasion and metastasis of HCC.