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目的 :探讨成人喉乳头状瘤及其癌变中的层黏蛋白 L aminin(L N)和 型胶原 (C )的表达与其生物学特性的关系。方法 :采用免疫组织化学 S- P法检测 10例喉息肉、2 3例喉乳头状瘤、12例喉乳头状瘤恶变组织中 L N、C 的表达。结果 :L N、C 的表达在喉息肉、喉乳头状瘤及癌变各组间均有显著性差异 ,其表达强度在有无淋巴结转移组间亦有明显差异。 3年以上生存组 L N、C 的表达明显高于 0 .5年内死亡组 (P<0 .0 1)。结论 :L N、C 的表达与组织分化和淋巴结转移有关 ,L N、C 的表达可作为评估喉乳头状瘤是否有癌变潜能及癌变者预后的指标
Objective: To investigate the relationship between the expression of Laminin (L N) and collagen (C) and their biological characteristics in laryngeal papilloma and its carcinogenesis. Methods: Immunohistochemical S-P method was used to detect the expression of L N, C in 10 cases of laryngeal polyps, 23 cases of laryngeal papilloma and 12 cases of laryngeal papilloma. Results: The expressions of L, C were significantly different between laryngeal polyps, laryngeal papilloma and carcinogenesis groups, and the expression intensity of L, C was also significantly different between the groups with or without lymph node metastasis. The expression of L N and C in the survival group more than 3 years was significantly higher than that in the 0 5 years death group (P <0 01). CONCLUSION: The expression of L, C is related to tissue differentiation and lymph node metastasis. The expression of L, C may be used as an index to evaluate the potential of carcinogenesis and the prognosis of laryngeal papilloma