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目的探讨沙格列汀联合二甲双胍治疗初发2型糖尿病患者的疗效。方法选取我院初诊的84例2型糖尿病患者,随机分为治疗组和对照组。治疗12周,治疗前后分别记录空腹血糖(FBG)、糖化血红蛋白(HbA1c)、餐后2小时血糖(2hPG)、空腹胰岛素(FIN),胰岛素抵抗指数(HomaIR)、胰岛素分泌指数(Homa-β)等变化。结果治疗后,2组的FBG、2hPG、HbA1c及HOMA-IR均明显下降(P<0.05),治疗组FIN及Homa-β较对照组明显增加(P<0.05)。结论沙格列汀联合二甲双胍对初发2型糖尿病患者的治疗疗效更显著。
Objective To investigate the effect of saxagliptin and metformin in the treatment of newly diagnosed type 2 diabetic patients. Methods 84 patients with type 2 diabetes mellitus newly diagnosed in our hospital were randomly divided into treatment group and control group. The levels of fasting blood glucose (FBG), HbA1c, 2hPG, FIN, HomaIR and Homa-β were recorded before and after treatment for 12 weeks. Other changes. Results After treatment, the levels of FBG, 2hPG, HbA1c and HOMA-IR in two groups were significantly decreased (P <0.05), and FIN and Homa-β in treatment group were significantly increased (P <0.05). Conclusion Saxagliptin combined with metformin is more effective in the treatment of newly diagnosed type 2 diabetic patients.