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目的探讨祛湿化瘀方治疗非酒精性脂肪性肝病的临床疗效。方法选取2010年6月—2014年6月交口县桃红坡中心卫生院收治的非酒精性脂肪性肝病患者86例,随机分为观察组与对照组,各43例。对照组患者予以多烯磷脂酰胆碱胶囊治疗,观察组患者予以祛湿化瘀方治疗。观察两组患者临床疗效、治疗前后肝功能、血脂情况及不良反应发生情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆固醇(TC)、三酰甘油(TG)水平比较,差异无统计学意义(P>0.05),治疗后观察组患者ALT、AST、TC、TG水平低于对照组(P<0.05),两组患者治疗后ALT、AST、TC、TG水平低于治疗前(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论祛湿化瘀方治疗非酒精性脂肪性肝病的临床疗效显著,可改善患者肝功能及血脂,且不良反应少,安全性高。
Objective To investigate the clinical efficacy of Qushi Huayu decoction in the treatment of non-alcoholic fatty liver disease. Methods Totally 86 patients with nonalcoholic fatty liver disease admitted from June 2010 to June 2014 in Taohongpo Central Hospital of Jiaokou County were randomly divided into observation group and control group, with 43 cases in each group. Patients in the control group were treated with polyene phosphatidylcholine capsules and patients in observation group were treated with Qushi Huayu decoction. The clinical curative effect, liver function, blood lipid and adverse reactions before and after treatment were observed. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P <0.05); before treatment, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) (P> 0.05). After treatment, the levels of ALT, AST, TC and TG in the observation group were lower than those in the control group (P <0.05), while the levels of TC, TG in the two groups The levels of ALT, AST, TC and TG in patients after treatment were lower than those before treatment (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Qu humid Huayu Recipe treatment of non-alcoholic fatty liver disease has a significant clinical effect, can improve liver function and blood lipids, and fewer adverse reactions, high safety.