地高辛(Digoxinum)是目前临床较常用的强心甙。治疗安全范围较小,是10种发生相互作用最多的药物之一。Leahey报告,因地高辛的相互作用而出现不良反应的发生率约为27%。临床上往往将这种毒副作用误认为是强心甙本身的中毒反应。近来国外有人报道,无论口服或静脉注射地高辛,均有部分在肠道远端(盲肠、结肠),被厌氧菌、双岐杆菌迅速代谢为地高辛的还原产物(DRPs)——双(?)地高辛 Digoxinum is more commonly used in clinical cardiac glycosides. One of the 10 drugs with the most interaction is the small safe range of treatment. Leahey reports about 27% of adverse reactions due to digoxin interactions. Clinically, this toxic side effects are often mistaken for the toxicity of cardiac glycosides. Recently, it has been reported that no matter oral or intravenous digoxin, there are some in the distal intestine (cecum, colon), anaerobic bacteria, bifidobacteria rapidly metabolized to digoxin reduction products (DRPs) - Double (?) Digoxin