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近几年来肺部给药传递系统已成为人们研究的新焦点,但将微粒转运到肺组织后微粒与肺泡巨噬细胞间的作用却很少被人关注。根据不同的疾病通过调控微粒与肺泡巨噬细胞的摄取作用能够提高药物的治疗作用。文章参考大量的文献,综述了一些常见疾病与巨噬细胞间的关系并总结了肺部给药传递系统中肺泡巨噬细胞对微粒摄取作用的影响因素,为肺部给药制剂的发展与临床应用奠定基础。
In recent years, pulmonary delivery system has become a new focus of research, but the role of the particles in the lung after the transfer of particles and alveolar macrophages is rarely concerned. According to different diseases by regulating the uptake of particles and alveolar macrophages can improve the therapeutic effect of drugs. This paper reviews a large number of literatures, summarizes the relationship between some common diseases and macrophages and summarizes the factors that affect the uptake of alveolar macrophages in the pulmonary delivery system. Application laid the foundation.