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含有未甲基化CpG基序的寡核苷酸序列(CpG ODN)能激活宿主的免疫系统,引起先天免疫应答和获得性免疫应答。CpG ODN诱导产生的细胞因子、活化的各种免疫细胞有明显的抗肿瘤作用。CpG ODN可通过多种途径发挥抗肿瘤作用,包括作为单独治疗剂、免疫佐剂或和其他免疫疗法共同治疗,也可以与放疗、化疗以及外科手术联合应用治疗肿瘤。CpG ODN的抗肿瘤活性已经在动物模型中得到证明,目前正以CpG ODN的这一特性为基础开发新型的抗肿瘤药物。有几种CpG ODN新药已经进入临床试验阶段,为肿瘤患者的治疗提供新的途径。
Oligonucleotide sequences containing unmethylated CpG motifs (CpG ODNs) activate the host’s immune system, causing innate and adaptive immune responses. CpG ODN induced cytokines, activated a variety of immune cells have a significant anti-tumor effect. CpG ODNs can exert anti-tumor effects in a variety of ways, including as a monotherapy, immunoadjuvant or in combination with other immunotherapies, as well as radiotherapy, chemotherapy and surgery. The antitumor activity of CpG ODN has been demonstrated in animal models and new antitumor drugs are currently being developed on the basis of this property of CpG ODN. Several new CpG ODN drugs have entered the clinical trial phase, providing a new way for the treatment of cancer patients.