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目的观察醒脑静对重症脑出血患者血清炎性因子水平的影响及神经保护作用。方法选取重症脑出血患者80例,随机分为观察组和对照组各40例。对照组予临床常规治疗措施,观察组在对照组基础上加用醒脑静治疗,借助双抗体夹心酶联合免疫吸附法测定2组患者在治疗后不同时间点的血清炎性因子含量,并分析其神经功能,探索醒脑静对脑出血的治疗效果。结果伤后1d观察组血清炎性因子水平与对照组无差异(P>0.05);伤后3、7及10d,观察组血清炎性因子明显低于对照组(P<0.05)。观察组不良反应发生率低于对照组,苏醒人数多于对照组,致残率低于对照组(P<0.05)。结论醒脑静用于重症脑出血治疗能够显著降低患者血清炎性因子的含量,并降低临床并发症发生率,改善患者的昏迷状态,值得临床推广应用。
Objective To observe the effects of xingnaojing on serum levels of inflammatory cytokines in patients with severe cerebral hemorrhage and its neuroprotective effects. Methods Eighty patients with severe intracerebral hemorrhage were randomly divided into observation group (40 cases) and control group (40 cases). The control group was given routine clinical treatment. The observation group was treated with xingnaojing on the basis of the control group. The levels of serum inflammatory cytokines at different time points after treatment were determined by double antibody sandwich enzyme-linked immunosorbent assay Its neurological function, to explore Xingnaojing treatment of cerebral hemorrhage. Results The levels of serum inflammatory cytokines in the observation group at 1 day after injury were not significantly different from those in the control group (P> 0.05). At 3, 7 and 10 days after injury, serum inflammatory factors in the observation group were significantly lower than those in the control group (P <0.05). The incidence of adverse reactions in the observation group was lower than that of the control group, and the number of awakening was more than that of the control group. The morbidity was lower than that of the control group (P <0.05). Conclusion Xingnaojing for severe intracerebral hemorrhage treatment can significantly reduce the serum levels of inflammatory cytokines and reduce the incidence of clinical complications and improve patients with coma, worthy of clinical application.