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肌动蛋白的聚合耦合三磷酸腺酐(ATP)分子水解成二磷酸腺苷(ADP)分子和磷酸(Pi)的释放两个过程.因此,肌动蛋白纤维上的原聚体存在三种不同状态,即分别结合ATP,ADP/Pi和ADP分子.原聚体的不同状态导致纤维具有不同的空间图谱,这些状态的空间分布将影响纤维的各种行为.为此,建立了相应的分子模型,在布朗动力学模拟中实现了遵循时间演化的连续马尔可夫随机过程的解聚和水解反应;重点阐述了如何实现纤维两端的聚合和解聚达到化学平衡的方法,并系统研究了纤维在结合ATP分子的肌动蛋白单体溶液中的增长行为.
Actin polymerization is coupled to the triphosphate triphosphate (ATP) molecule to hydrolyze adenosine diphosphate (ADP) molecules and phosphate (Pi) in the release of two processes.Therefore, actin fiber on the existence of three different State, that is, they bind to ATP, ADP / Pi and ADP molecules respectively.Different states of the original polymer lead to different spatial patterns of the fibers, and the spatial distribution of these states will affect the fiber behavior.For this purpose, a corresponding molecular model , The depolymerization and hydrolysis reactions of continuous Markov random process following the evolution of time are realized in the Brownian dynamics simulation. The methods of how to achieve the chemical equilibrium by polymerization and depolymerization at both ends of the fiber are emphatically elaborated. Growth behavior of ATP molecule in actin monomer solution.