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据2017年5月13日《科技日报》报道,中国科技大学生科院高平课题组和张华凤课题组的合作研究发现,组蛋白甲基化转移酶复合物中的一个共调控因子Menin在c-Myc介导的基因调控、肿瘤代谢和肿瘤发生发展过程中发挥重要作用,Menin实际是通过增强c-Myc的转录活性来影响体内外肿瘤细胞的代谢及增殖的。这项研究不仅确定Menin是c-Myc转录活性的促进因子,还揭示了Menin行使癌基因功
According to the report of Science and Technology Daily on May 13, 2017, a collaborative study by the Gao Ping Task Group of the Chinese Academy of Science and Technology’s CASS and Zhang Hua-feng’s research group found that Menin, a co-regulatory factor in the histone methyltransferase complex, Mediated gene regulation, tumor metabolism and tumor development play an important role in the process, Menin actually through the enhancement of c-Myc transcriptional activity to affect tumor cells in vitro and in vivo metabolism and proliferation. This study not only confirmed that Menin is a promoter of c-Myc transcriptional activity but also revealed that Menin exerts oncogene function