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本文用双盲法比较了DT-百日咳无细胞菌苗(DTP-AC)和DT-百日咳全菌体菌苗(DTP-WC)对婴儿的免疫原性和反应原性。19名婴儿接种DTP-AC,20名婴儿接种DTP-WC。结果表明,接种DTP-AC婴儿的发热、局部肿胀和全身反应等异常反应比接种DTP-WC组明显减少。在接种第3针后第7天,DTP-WC组有5/18、DTP-AC组有1/19的婴儿局部出现>5mm的硬结,第14天DTP-WC组有3/17、DTP-AC组有0/12的婴儿有硬结。未见脑病,惊厥或休克/虚脱。两组血清学反应显不同。3次免疫后,
This article compared the immunogenicity and the reactivity of DT-pertussis acellular vaccine (DTP-AC) and DT-pertussis whole-cell vaccine (DTP-WC) to infants by double- 19 infants received DTP-AC and 20 infants received DTP-WC. The results showed that the incidence of fever, local swelling and systemic reactions in DTP-AC infants decreased significantly compared with DTP-WC group. At day 7 after inoculation of the third needle, there were 5/18 in the DTP-WC group, 1 mm in the DTP-AC group, and 5% in the DTP-WC group on the 14th day. DTP- The 0/12 infants in the AC group had induration. No encephalopathy, convulsions or shock / collapse. Serological response was significantly different between the two groups. After 3 immunizations,