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目的探讨登革热并发肝损害的临床特征。方法收集2014年广州市第八人民医院收治的343例登革热患者的临床资料,对其进行回顾性分析。结果 343例登革热患者中,排除病毒性肝炎、脂肪肝、酒精肝、药物性肝损害及溶血等其他原因可能引起的肝功能损伤者,共293例。登革热病例显示肝脏损害发生率较高,ALT异常占76.03%,AST异常占88.40%,该组患者ALT、AST达到峰值的病程天数分别为(8.59±2.56)d、(7.5±2.24)d。年龄小于20岁登革热患者占4.5%,20岁至40岁之间登革热患者占26.4%,40岁至60岁之间登革热患者占28.4%,60岁以上占16.8%。结论登革热并发肝损害发生率高,主要表现在转氨酶升高,以轻中度多见,且转氨酶升高多处于病程中后期,以成年人为主,中青年患者比例高,经过积极护肝降酶治疗恢复较快、预后良好。
Objective To investigate the clinical features of dengue fever complicated with liver damage. Methods The clinical data of 343 dengue patients admitted to Eighth People ’s Hospital of Guangzhou in 2014 were retrospectively analyzed. Results A total of 293 patients with dengue fever were excluded from the liver damage caused by other causes such as viral hepatitis, fatty liver, alcoholic liver, drug-induced liver damage and hemolysis. The incidence of liver damage was higher in dengue cases. The ALT abnormalities accounted for 76.03% and AST abnormalities accounted for 88.40%. The duration of ALT and AST peaked in this group was (8.59 ± 2.56) days and (7.5 ± 2.24) days, respectively. Dengue patients aged less than 20 years accounted for 4.5%, dengue patients aged 20-40 years accounted for 26.4%, between 40 and 60 years of age accounted for 28.4% of dengue patients, 16.8% over the age of 60. Conclusion The incidence of dengue fever complicated with liver injury is high, mainly in the elevated transaminases, mild to moderate more common, and elevated transaminases in the late course of the disease, mainly in adults, a high proportion of young patients, after active protection of liver enzymes Treatment recovered quickly and the prognosis was good.