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目的探讨妊娠梅毒患者应用阿奇霉素与苄星青霉素G防治先天性梅毒的临床效果。方法选取2012年6月-2016年6月肇庆市端州区妇幼保健院收治的90例妊娠梅毒患者。按照随机数字表法随机分为阿奇霉素组与苄星青霉素G组各45例,对两组患者的临床疗效及正常分娩的新生儿有效率进行比较分析。结果阿奇霉素组与苄星青霉素G组的正常分娩的新生儿有效率及治疗后快速血清反应素的试验滴度变化比较,差异无统计学意义(P>0.05)。结论妊娠梅毒患者应用阿奇霉素与苄星青霉素G防治先天性梅毒的临床效果相当,妊娠梅毒患者若存在对青霉素过敏,可使用阿奇霉素作为替代治疗。
Objective To investigate the clinical efficacy of azithromycin and benzathine penicillin G in the prevention and treatment of congenital syphilis in pregnant women with syphilis. Methods From June 2012 to June 2016, 90 pregnant women with syphilis were enrolled in the Duanzhou MCH hospital in Zhaoqing City. According to random number table method randomly divided into azithromycin group and benzathine penicillin G group of 45 cases, the clinical efficacy of two groups of patients and normal delivery of neonates were compared. Results There was no significant difference in the effective rate of newborn infants in azithromycin group and benzathine penicillin G group and the test titer of rapid serum serotonin after treatment (P> 0.05). Conclusion Pregnancy syphilis patients with azithromycin and penicillin G prevention and treatment of congenital syphilis clinical effect is quite, if pregnant women with syphilis if there is allergy to penicillin, azithromycin can be used as an alternative treatment.