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目的观察调脂治疗对不稳定型心绞痛患者血浆C-反应蛋白(CRP)及纤维蛋白原(FIB)的影响。方法选择不稳定型心绞痛患者74例,随机分为治疗组和对照组,各37例,对照组常规治疗,治疗组给予阿托伐他汀和常规治疗,测定治疗前后血浆CRP,FIB及胆固醇(TC)水平,并进行比较。结果 74例不稳定心绞痛患者中,37例调脂治疗组CRP,FIB,TC等与对照组相比均明显下降。对照组CRP(9.75±4.88)mg·L- 1,FIB(4.18±1.05)mg·L-1,TC(5.26±0.64)mmol·L-1,调脂治疗组CRP(6.79±3.95)mg·L-1,FIB(2.84±0.98)mg·L-1,TC(4.58±0.9)mmol·L-1,调脂治疗组和对照组CRP和FIB比较P值均<0.01,2组TC比较P<0.05,2组对比有显著差异。结论调脂治疗对不稳定型心绞痛具有明显的抗血管内皮炎症反应的作用。
Objective To observe the effects of lipid-lowering therapy on plasma C-reactive protein (CRP) and fibrinogen (FIB) in patients with unstable angina pectoris. Methods 74 patients with unstable angina pectoris were randomly divided into treatment group and control group, 37 cases in each group. The control group received routine treatment, the treatment group received atorvastatin and routine treatment. The levels of plasma CRP, FIB and cholesterol ) Level, and make a comparison. Results Among the 74 patients with unstable angina pectoris, CRP, FIB, TC and so on in 37 cases of lipid-lowering treatment group were significantly decreased compared with the control group. The CRP levels in control group were (9.75 ± 4.88) mg · L -1, FIB (4.18 ± 1.05) mg · L -1, TC (5.26 ± 0.64) mmol·L -1 and CRP (6.79 ± 3.95) mg · (P <0.05). The P values of CRP and FIB in the lipid-lowering treatment group and the control group were all less than 0.01 (P <0.01) <0.05, 2 groups were significantly different. Conclusion Lipid-lowering therapy has obvious anti-vascular endothelium inflammatory response to unstable angina pectoris.