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本实验用三氧化二锑(Sb_2O_3)对大鼠进行多次连续性染尘,分次观察肺干重、肺胶原蛋白及肺组织病理改变。发现随染尘次数增加,肺干重夏肺胶原蛋白含量逐渐增加并出现显著性差异(P>0.01,P>0.05)。病理观察可见细胞一纤维性结节。提示长期反复吸入Sb_2O_3粉尘,可引起肺组织一定程度的纤维化病变。
In this experiment, antimony trioxide (Sb_2O_3) was used to stain the lungs of rats continuously for several times. The dry weights of lungs, lung collagen and pathological changes of lung tissue were observed. It was found that with the increase of the number of dyed dust, the content of collagen in lung of dry lung increased gradually and showed significant difference (P> 0.01, P> 0.05). Pathological observation of a fibrous cell nodules. Tip long-term repeated inhalation of Sb 2 O 3 dust, can cause some degree of lung fibrosis lesions.