用于治疗糖尿病的常规胰岛素制剂为80％牛胰岛素和20％猪胰岛索的合剂。反复注射这些异种胰岛素可产生 IgG 抗体,后者可与注入体内的部分胰岛素结合。牛胰岛素与人胰岛素有几个氨基酸部位不同,而猪胰岛素与人胰岛素仅有一个部位差异,因此,牛胰岛素比猪胰岛素更有免疫源性。通常是胰岛素合剂中的牛胰岛素引起 IgG 抗体水平增高和胰岛素抗药性,这种抗牛胰岛素抗体对猪胰岛素和人胰岛素都有交叉反应性。成年发病型糖尿病患者体内往往有大量内源性胰岛素分泌,这类患者用胰岛素治疗后所引起的高 Conventional insulin preparations for the treatment of diabetes are a combination of 80% bovine insulin and 20% porcine isthmus. Repeated injections of these xenoins produce IgG antibodies, which bind to a portion of the insulin that is injected into the body. There are several amino acid positions for bovine insulin and human insulin, but there is only one part between porcine insulin and human insulin. Therefore, bovine insulin is more immunogenic than porcine insulin. Bovine insulin, usually in insulin mixes, causes increased levels of IgG antibodies and insulin resistance. Such anti-bovine insulin antibodies are both cross-reactive to porcine insulin and human insulin. Adult patients with type diabetes usually have a large number of endogenous insulin secretion, such patients with insulin-induced high