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目的观察肾移植术后早期(6个月内)肺部感染患者淋巴细胞总数(total lymphocyte count,TLC)、巨细胞病毒抗体(CMV-IgM)水平的变化。方法通过回顾南华大学附属第二医院2013年1月1日—2015年5月1日进行的47例同种异体肾移植受者,追踪其术后6个月内肺部感染发生情况,并分为感染组7例与非感染组40例。用血细胞分析仪测定研究对象外周血TLC,用化学发光法检测CMV-IgM值。采用SPSS17.0统计学软件进行统计分析,P<0.05为差异有统计学意义。结果 1肾移植受者感染组与非感染组术前间TLC比较,差异无统计学意义(F=2.214,P=0.144);2肾移植受者感染组与非感染组术前之间CMV-IgM值比较,差异无统计学意义(Z=-1.801,P=0.072);3肾移植术后第10周、11周、12周、16周感染组TLC低于非感染组,差异有统计学意义(P<0.05);4肾移植术后感染组CMV-IgM值高于非感染组,差异有统计学意义(P<0.05)。结论肾移植术后早期肺部感染患者外周血TLC水平降低,CMV-IgM水平升高。
Objective To observe the changes of total lymphocyte count (TLC) and cytomegalovirus antibody (CMV-IgM) in patients with pulmonary infection in the early stage (within 6 months) after kidney transplantation. Methods By reviewing 47 cases of allograft recipients from January 1, 2013 to May 1, 2015 in Second Affiliated Hospital of Nanhua University, the incidence of pulmonary infection within 6 months after operation was tracked and divided into two groups 7 cases in infected group and 40 cases in non-infected group. The hematocrit was used to measure the peripheral blood TLC, and the chemiluminescence method was used to detect the CMV-IgM. SPSS17.0 statistical software for statistical analysis, P <0.05 for the difference was statistically significant. Results There was no significant difference in preoperative TLC between two groups (F = 2.214, P = 0.144). 2 The correlation between CMV- IgM values in the infected group were significantly lower than those in the non-infected group (Z = -1.801, P = 0.072); 3 The levels of TLC in the 10, 11, 12 and 16 weeks after renal transplantation were lower than those in the non-infected group (P <0.05). 4 The CMV-IgM in renal transplantation group was significantly higher than that in non-infected group (P <0.05). Conclusion In peripheral blood of patients with early lung infection after renal transplantation, the level of TLC is decreased and the level of CMV-IgM is increased.