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目的评价人宫颈癌基因(HCCR)在原发性肝癌(primary hepatic carcinoma,PHC)诊断中的作用。方法分析40例原发性肝癌患者、40例慢性肝病患者与40名体检者血清中HCCR的水平,应用受试者工作特性曲线(ROC)对HCCR检测结果进行分析评价。结果①40例肝癌组HCCR浓度(136.850IU/L±74.671IU/L)高于肝病组(65.165IU/L±18.359IU/L)和对照组(71.368IU/L±16.014IU/L),差异有统计学意义(P=0.000)。②HCCR、AFP诊断原发性肝癌ROC曲线下面积分别为0.863、0.973。③在诊断原发性肝癌方面,HCCR与AFP无明显相关性(r=0.268,P=0.003)。结论 HCCR对PHC有重要的诊断价值,且与AFP无明显相关性,可作为AFP的补充诊断PHC。
Objective To evaluate the role of human cervical cancer gene (HCCR) in the diagnosis of primary hepatic carcinoma (PHC). Methods The serum levels of HCCR in 40 patients with primary liver cancer, 40 patients with chronic liver disease and 40 subjects were analyzed. The HCCR test results were analyzed and evaluated using the receiver operating characteristic curve (ROC). Results ① The HCCR concentration of 136 HCC patients (136.850 IU / L ± 74.671 IU / L) was significantly higher than that of the liver disease patients (65.165 IU / L ± 18.359 IU / L) and the control group (71.368 IU / L ± 16.014 IU / L) Statistical significance (P = 0.000). ② The area under the ROC curve of the diagnosis of primary liver cancer by HCCR and AFP were 0.863 and 0.973, respectively. ③ In the diagnosis of primary liver cancer, HCCR and AFP no significant correlation (r = 0.268, P = 0.003). Conclusion HCCR has an important diagnostic value for PHC, and has no obvious correlation with AFP, and can be used as a supplementary diagnostic PHC for AFP.