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运用正相硅胶、Sephadex LH-20、聚酰胺、制备型HPLC等多种色谱方法从野灯心草地上部分分离纯化得到10个菲类化合物和4个其他类化合物。经质谱、NMR谱图解析鉴定结构,分别为厄弗酚(1)、灯心草酚(2)、juncuenin D(3)、去氢厄弗酚(4)、去氢灯心草酚(5)、juncuenin B(6)、dehydrojuncuenin B(7)、2-甲氧基-7-羟基-1-甲基-5-乙烯基菲(8)、2-羟基-7-羧基-1-甲基-5-乙烯基-9,10-二氢菲(9)、2-羟基-7-羧基-1-甲基-5-乙烯基菲(10)、木犀草素(11),香草酸(12)、瑞香素(13)、对香豆酸(14)。其中,化合物13为首次从该属植物中分离得到,化合物5,8~12为首次从该植物中分离得到。采用小鼠高架十字迷宫实验评价菲类化合物6和7的抗焦虑活性,结果表明化合物6和7均具有抗焦虑作用。
A total of 10 phenanthrene and 4 other compounds were isolated and purified from the aboveground part of Rhizophora stylosa by using silica gel, Sephadex LH-20, polyamide and preparative HPLC. The structures of the compounds were identified by mass spectrometry and NMR spectroscopy. The structures were identified as: Eugenol (1), kanamycin (2), juncuenin D (3), dehydroforteol (4) (6), dehydrojuncuenin B (7), 2-methoxy-7-hydroxy-1-methyl-5-vinylphenanthrene (8) (9), 2-hydroxy-7-carboxy-1-methyl-5-vinylphenanthrene (10), luteolin (11), vanillic acid (12), daphnetin (13), p-coumaric acid (14). Among them, compound 13 was isolated from this genus for the first time, and compounds 5 and 8 to 12 were isolated from this plant for the first time. The anti-anxiety activities of phenanthrene compounds 6 and 7 were evaluated using mouse elevated plus maze test. The results showed that both compounds 6 and 7 have anti-anxiety effects.