目的 :探讨冠心病 (CHD)患者对氧磷酯酶 1(Paraoxonase 1,PON1)基因多态性与血脂的关系及其病因学意义。方法 :使用Taqman特异性等位基因鉴别法检测 93例CHD患者和 138例健康对照者的基因组DNA ,测定该基因G 12 6C、L5 5M和Q192R三个多态性的基因型和由三个位点的等位基因组成的单体型。统计分析两组间这些基因型和单体型频率分布差异性 ,以及不同基因型与血脂水平的相关性。结果 :CHD患者中Q192R位点的QQ基因型携带者明显少于健康对照者 (7.5 %∶18.1% ,P <0 .0 5 ) ,各种单体型在两组间差异无显著性意义。各基因型之间血脂水平差异亦无显著性意义。结论 :PON1基因中只有Q192R多态性与CHD的发病相关 Objective: To investigate the relationship between paraoxonase 1 (PON1) gene polymorphism and serum lipids in patients with coronary heart disease (CHD) and its etiological significance. Methods: The genomic DNAs of 93 CHD patients and 138 healthy controls were detected by Taqman-specific allele. The genotypes of G 12 6C, L 5 5M and Q192R were determined by three genotypes Point haplotypes haplotypes. Statistical analysis of these two genotypes and haplotype frequency distribution differences, as well as different genotypes and blood lipid levels. Results: Q192R loci of CHD patients were significantly less than those of healthy controls (7.5% vs 18.1%, P <0.05). There was no significant difference in the haplotypes between the two groups. There was no significant difference in the level of plasma lipids between genotypes. Conclusion: Only Q192R polymorphism in PON1 gene is associated with the pathogenesis of CHD