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目的检测2型糖尿病(T2DM)患者的肺通气、弥散功能及糖化血红蛋白(HbA1c)含量,探讨肺是否为糖尿病慢性病变的靶器官及同时观察HbA1c含量的意义。方法检测90例2型糖尿病患者(根据有无微血管病变、眼底、肾脏及神经系统病变再分为无并发症组50例和有并发症组40例)肺通气功能—肺活量(VC)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占用力肺活量百分比(FEV1/FVC,FEV1.0%)用力呼中期流速FEF25%～75%,肺弥散功能—肺一氧化碳弥散量(DLCO)及HbA1c含量,与50名健康者相比较。结果 2型糖尿病组无并发症组肺通气功能、弥散功能与正常对照组相比差异无统计学意义(P均﹥0.05),有并发症组与无并发症VC、FVC、FEV1、LDCO差异有统计学意义(P均﹤0.05),3组间HbA1c差异有统计学意义(P均﹤0.05),HbA1c含量与肺通气功能、弥散功能呈负相关。结论 T2DM患者随着病情的进展发生并发症时,肺通气功能、弥散功能障碍,HbA1c可作为观察2型糖尿病患者肺功能受损指标之一。
Objective To investigate the pulmonary ventilation, diffuse function and HbA1c in patients with type 2 diabetes mellitus (T2DM), and to investigate whether lungs are the target organ of chronic diabetic diseases and to observe the significance of HbA1c. Methods 90 patients with type 2 diabetes mellitus (pulmonary function - vital capacity (VC), forced vital capacity (FEV1), FEV1, FEV1, FEV1% FEV1 / FVC, FEV1.0% Velocity of interphalangeal FEF25% ~ 75%, pulmonary diffuse function - Lung carbon monoxide dispersion (DLCO) and HbA1c levels, compared with 50 healthy subjects. Results Compared with the normal control group, there was no significant difference in the function of pulmonary ventilation between the two groups of type 2 diabetes mellitus patients without complication (P> 0.05). There was significant difference between the complication group and the non-complications VC, FVC, FEV1, LDCO (All P <0.05). The difference of HbA1c between the three groups was statistically significant (P <0.05). The content of HbA1c was negatively correlated with pulmonary function and diffusion function. Conclusions With the progression of disease, complications such as pulmonary ventilation, diffuse dysfunction and HbA1c may be considered as one of the indicators of lung function impairment in type 2 diabetic patients.